Evaluation of the potential carcinogenicity of cadmium, cadium acetate, cadmium bromide, cadmium chloride. Final report
Cadmium is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is Limited. The potency factor (F) for cadmium is estimated to be 57.9/(mg/kg/day) (based on epidemiology data for cadmium workers), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Cadmium weight of evidence and potency are based on epidemiology data for cadmium workers exposed to cadmium oxide and/or cadmium fume. Although human data for cadmium salts are lacking, due to the responsiveness of animals to soluble cadmium compounds, especially cadmium chloride, the weight of evidence and potency for cadmium acetate, cadmium bromide and cadmium chloride are considered to be the same as those cadmium compounds to which workers are exposed. Thus, cadmium acetate, cadmium bromide, and cadmium chloride are all classified as weight-of-evidence Group and the potency group, cadmium, cadmium acetate, cadmium bromide, and cadmium chloride are assigned MEDIUM hazard rankings for the purposes of RQ adjustment. Combining the weight-of-evidence group and the potency group, carbon tetrachloride is assigned a MEDIUM hazard ranking for the purposes of RQ adjustment.
- Research Organization:
- Syracuse Research Corp., NY (United States)
- OSTI ID:
- 6428405
- Report Number(s):
- PB-93-185106/XAB; CNN: EPA-68-03-3112; EPA-68-03-3182
- Resource Relation:
- Other Information: See also PB--81-117368 and PB--85-243533
- Country of Publication:
- United States
- Language:
- English
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29 ENERGY PLANNING
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ACETATES
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CADMIUM BROMIDES
CADMIUM CHLORIDES
CADMIUM HALIDES
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