Evaluation of the potential carcinogenicity of chromium and hexavalent chromium compounds. Final report

Technical Report · Wed Jun 01 04:00:00 EDT 1988

OSTI ID:6428381

Hexavalent chromium compounds are human carcinogens, classified as weight-of-evidence Group A (based on chromate production workers and animal data which indicates that inhaled hexavalent chromium compounds are carcinogenic) under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is Sufficient. As stated in the U.S. EPA Health Assessment Document on chromium and compounds, metallic chromium is biologically inert and has not been reported to produce tumors in man or animal models. The no data are available on the carcinogenicity of metallic chromium. The potency factor (F) for hexavalent chromium is estimated to be 389/(mg/kg/day) (based on epidemiological data for the inhalation of hexavalent chromium by chromate workers), placing it in potency group 1 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, all of the hexavalent chromium compounds are assigned a HIGH hazard ranking for the purposes of RQ adjustment.

• Research Organization: Syracuse Research Corp., NY (United States)
• OSTI ID: 6428381
• Report Number(s): PB-93-185148/XAB; CNN: EPA-68-03-3112; EPA-68-03-3182
• Country of Publication: United States
• Language: English

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29 ENERGY PLANNING, POLICY, AND ECONOMY
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
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CHROMIUM
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