Tubocurarine has no clear effect on the metabolism of exogenous arachidonic acid in hamster isolated lungs

Journal Article · Tue Nov 01 04:00:00 EST 1983 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:6414063

Suves, M; Uotila, P

The effect of tubocurarine on the metabolism of exogenous 14C-arachidonic acid (14C-AA) was investigated in isolated perfused hamster lungs. When 40 nmol of 14C-AA was infused in two minutes into the pulmonary circulation the perfusion pressure increased and 14C-AA metabolized to prostaglandins, thromboxane and lipoxygenase metabolites which were analyzed from the nonrecirculating perfusion effluent. When tubocurarine (4 or 40 micrograms/ml) was infused into the pulmonary circulation the increase in the perfusion pressure was not changed and the amounts of arachidonate metabolites were not changed dose dependently. At 4 micrograms/ml tubocurarine slightly decreased the amount of some prostaglandins (eg. PGE2) but with the higher concentration of 40 micrograms/ml no significant changes were detected. The present study indicates that tubocurarine has no clear dose dependent effect on the metabolism of exogenous arachidonic acid in hamster lungs.

• Research Organization: Univ. of Turku, Finland
• OSTI ID: 6414063
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 42:2; ISSN RCOCB
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARACHIDONIC ACID
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
DRUGS
HAMSTERS
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LUNGS
MAMMALS
METABOLISM
METABOLITES
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SYMPATHOMIMETICS
TISSUE CULTURES
TRACER TECHNIQUES
VERTEBRATES