The effect of ionic and nonionic contrast media on the metabolism of prostaglandin E2 in rat lungs
Journal Article
·
· Invest. Radiol.; (United States)
Pulmonary inactivation of prostaglandin E2 (PGE2) was investigated in isolated perfused rat lungs during infusion of ionic and nonionic radiographic contrast media (RCM). When 100 nmol of (14C)-PGE2 was infused slowly into the pulmonary circulation, the ionic ioglycamate decreased the metabolism of PGE2, but other ionic (diatrizoate and ioxaglate) and nonionic RCM (iopamidol and metrizamide) had no significant effect. When a smaller amount of (14C)-PGE2 (10 nmol) was injected as a bolus the metabolism of PGE2 was decreased also by diatrizoate and ioxaglate, but not by iopamidol. After a similar bolus injection of 10 nmol of (14C)-PGE2, the efflux of radioactivity from the lungs was increased by diatrizoate, ioglycamate and ioxaglate but remained unchanged by iopamidol and metrizamide. The RCM infusion did not change the perfusion pressure. The present study indicates that ionic RCM decrease the inactivation of PGE2 in rat lungs and thus possibly increase the circulating level of this prostaglandin.
- Research Organization:
- Department of Physiology, University of Turku, Finland
- OSTI ID:
- 6310162
- Journal Information:
- Invest. Radiol.; (United States), Journal Name: Invest. Radiol.; (United States) Vol. 19:3; ISSN INVRA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Tubocurarine has no clear effect on the metabolism of exogenous arachidonic acid in hamster isolated lungs
Cigarette smoke ventilation decreases prostaglandin inactivation in rat and hamster lungs
The effect of cigarette smoke on the metabolism of arachidonic acid in isolated hamster lungs
Journal Article
·
Mon Oct 31 23:00:00 EST 1983
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
·
OSTI ID:6414063
Cigarette smoke ventilation decreases prostaglandin inactivation in rat and hamster lungs
Journal Article
·
Tue Jun 01 00:00:00 EDT 1982
· Prostaglandins; (United States)
·
OSTI ID:6563146
The effect of cigarette smoke on the metabolism of arachidonic acid in isolated hamster lungs
Journal Article
·
Wed Dec 31 23:00:00 EST 1980
· Prostaglandins; (United States)
·
OSTI ID:5611728