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The effect of cigarette smoke on the metabolism of arachidonic acid in isolated hamster lungs

Journal Article · · Prostaglandins; (United States)
OSTI ID:5611728
; ; ; ;
The effects of cigarette smoke on the metabolism of exogenous arachidonic acid (AA) were investigated in isolated hamster lungs. Arachidonate was injected into the pulmonary circulation and the metabolites were analysed from the nonrecirculating perfusion effluent by thin layer chromatography. After the pulmonary injection of 66 nmol of 14C-AA about 20% of the injected radioactivity appeared in the perfusion effluent mostly as metabolites in six minutes. When isolated lungs were ventilated with cigarette smoke during the perfusion, the amounts of PGF2 alpha, PGE2 and two unidentified metabolite groups increased in the lung effluent. In two other experimental series hamsters were exposed to cigarette smoke before the lung perfusion either once for 30 min or during one hour daily for ten consecutive days. Neither pre-exposures caused any changes in the amounts of arachidonate metabolites in the lung effluent.
Research Organization:
Department of Physiology, University of Turku, Turku, Finland
OSTI ID:
5611728
Journal Information:
Prostaglandins; (United States), Journal Name: Prostaglandins; (United States) Vol. 22:2; ISSN PRGLB
Country of Publication:
United States
Language:
English

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Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
ARACHIDONIC ACID
BIOLOGICAL EFFECTS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CHROMATOGRAPHY
COLLOIDS
DISPERSIONS
HAMSTERS
LABELLED COMPOUNDS
LUNGS
MAMMALS
METABOLISM
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROSTAGLANDINS
RADIONUCLIDE KINETICS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
SMOKES
SOLS
THIN-LAYER CHROMATOGRAPHY
TOBACCO SMOKES
VERTEBRATES