Cigarette smoke ventilation decreases prostaglandin inactivation in rat and hamster lungs
The effects of cigarette smoke on the metabolism of exogenous PGE2 and PGF2 alpha were investigated in isolated rat and hamster lungs. When isolated lungs from animals were ventilated with cigarette smoke during pulmonary infusion of 100 nmol of PGE2 or PGF2 alpha, the amounts of the 15-keto-metabolites in the perfusion effluent were decreased. Pre-exposure of animals to cigarette smoke daily for 3 weeks did not change the metabolism of PGE2 when the lungs were ventilated with air. Cigarette smoke ventilation of lungs from pre-exposed animals caused, however, a similar decrease in the metabolism of PGE2 as in animals not previously exposed to smoke. After pulmonary injection of 10 nmol of /sup 14/C-PGE2 the radioactivity appeared more rapidly in the effluent during cigarette smoke ventilation suggesting inhibition of the PGE2 uptake mechanism. In rat lungs pulmonary vascular pressor responses to PGE2 and PGF2 alpha were inhibited by smoke ventilation.
- Research Organization:
- Department of Physiology, University of Turku, Finland
- OSTI ID:
- 6563146
- Journal Information:
- Prostaglandins; (United States), Journal Name: Prostaglandins; (United States) Vol. 23:6; ISSN PRGLB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBON 14 COMPOUNDS
COLLOIDS
DISPERSIONS
HAMSTERS
IN VITRO
INHIBITION
LABELLED COMPOUNDS
LUNGS
MAMMALS
METABOLISM
METABOLITES
ORGANS
PERFUSED ORGANS
PROSTAGLANDINS
RATS
RESIDUES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
SMOKES
SOLS
TOBACCO SMOKES
UPTAKE
VERTEBRATES