Comparison of leukocytes labeled with indium-111-2-mercaptopyridine-N-oxide and indium-111 oxine for abscess detection
Indium-111 leukocyte scanning has evolved into a practical and highly accurate method for the identification of infectious and inflammatory processes. The most commonly used agent for labeling leukocytes has been (/sup 111/In)oxine. We have investigated a newer agent, 2-mercaptopyridine-N-oxide (Merc) at our institution which unlike oxine, allows us to label leukocytes in plasma, using a simple kit procedure. Of the 92 consecutive patients referred for detection or localization of an infectious process, autologous leukocytes of 55 patients were labeled with (/sup 111/In)Merc, while those of the remaining 37 patients were labeled with (/sup 111/In)oxine. The sensitivities for Merc and oxine procedures were 87% and 92%, respectively, while the respective specificities were 100% and 92%. We conclude that the (/sup 111/In)Merc-labeled leukocytes are equally effective as (/sup 111/In)oxine-labeled leukocytes in detecting infectious processes. The use of (/sup 111/In)Merc is advantageous over (111In)oxine for white blood cell labeling because of its easier preparation.
- Research Organization:
- Thomas Jefferson Univ. Hospital, Philadelphia, PA
- OSTI ID:
- 6408250
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 4; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Evaluation of indium-111-2-mercaptopyridine-N-oxide for labeling leukocytes in plasma: a kit preparation
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSCESSES
AROMATICS
AZAARENES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
LEUKOCYTES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOMETALLIC COMPOUNDS
OXINE
PATHOLOGICAL CHANGES
PATIENTS
PYRIDINES
QUINOLINES
RADIOISOTOPE SCANNING
RADIOISOTOPES