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Comparison of In-111-MERC leukocytes with In-111-Oxine leukocytes for abscess detection

Conference · · J. Nucl. Med.; (United States)
OSTI ID:5976247
; ; ;

This study was done to compare the clinical results of generally accepted Indium-111-oxine (oxine) labeled leukocytes with a relatively newer Indium-111-2-Mercaptopyridine-N-oxide (Merc) labeled leukocytes for the detection of occult abscesses. Of the 74 patients suspected of harboring an occult abscess, autologous leukocytes of 34 patients were labeled with oxine while in 40 patients Merc labeled leukocytes were used. Whole body imaging was performed at 24 hours. Interpretation of the scans was done without the knowledge of the leukocyte label (i.e. oxine vs Merc). The diagnosis was confirmed in each case by either subsequent clinical course, radiographic correlation (CT, US, etc.), surgery pathology, or autopsy. The results presented in this paper indicate that there is no significant difference between the Merc and oxine labeled leukocytes for abscess detection. The ease of labeling and potential availability of Merc as a kit is an advantage.

Research Organization:
Thomas Jefferson Univ. Hospital, Philadelphia, PA
OSTI ID:
5976247
Report Number(s):
CONF-850611-
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSCESSES
AROMATICS
AZAARENES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC USES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
LEUKOCYTES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXINE
PATHOLOGICAL CHANGES
PYRIDINES
QUINOLINES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
UPTAKE
USES