Microdosimetric TLD measurements for tumor associated antibody therapy

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6403462

Wessels, B W; Bacha, P; Quadri, S M

Currently, radiation dose in experimental tumored animals undergoing radioimmunotherapy trials is computed indirectly by assessing serial time-dependent biodistribution data, mean residence times and cumulated activities. These data are then used to calculate organ doses through the standard MIRD formalism. Substantial uncertainty in the absorbed organ doses are a result of model dependent assumptions regarding geometrical and radiation attenuation factors for heterogeneous tissue equivalent medium. The authors have developed a method for the direct verification of absorbed radiation dose through the use of teflon-imbedded, Teledyne CaSO/sub 4/:Dy thermoluminescent dosimeters (TLD) which have been modified to fit inside a 20 gauge needle. Typical TLD dimensions are in a rod-shape configuration of 0.2 x 0.5 x 5mm.

• Research Organization: George Washington Univ., Washington, DC
• OSTI ID: 6403462
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
CALIBRATION
DATA ANALYSIS
DESIGN
DISEASES
DISTRIBUTION
DOSEMETERS
DOSES
DOSIMETRY
DRUGS
IMMUNOLOGY
IMPLANTS
LABELLED COMPOUNDS
LUMINESCENT DOSEMETERS
MAMMALS
MEASURING INSTRUMENTS
MEDICINE
MELANOMAS
MICE
MICRODOSIMETRY
MODIFICATIONS
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
PERFORMANCE
RADIATION DOSES
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RODENTS
THERAPY
THERMOLUMINESCENT DOSEMETERS
THERMOLUMINESCENT DOSIMETRY
TISSUE DISTRIBUTION
VERTEBRATES