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Miniature thermoluminescent dosimeter absorbed dose measurements in tumor phantom models

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5014431
;
Miniature teflon-imbedded CaSO/sub 4/:Dy thermoluminescent dosimeter(s) (TLD) have been sized and cut to fit inside a syringe needle. These dosimeters have been shown to be linear in response to beta and high energy gamma radiation. This allows for their direct implantation into tumor-bearing animals undergoing radioimmunotherapy and subsequent measurement of dose deposition on a per organ basis. In order to perform these radiolabeled antibody dose measurements with sufficient accuracy, static calibration data must first be generated. Consequently, phantom models were constructed with artificial tumors of diameters ranging from 3-30 mm contained in a surrounding tissue equivalent medium. The TLD were used to characterize dose distributions in a radial direction from the center of the cylindrical tumor volumes containing /sup 131/I, /sup 32/P, or /sup 90/Y radionuclides. Absorbed dose measurements in the boundary region between tumor and outer medium were found to be dependent on the: tumor specific activity, average range of the beta radiation, and radial tumor dimensions.
Research Organization:
George Washington Univ., Washington, DC
OSTI ID:
5014431
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 8; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
61 RADIATION PROTECTION AND DOSIMETRY
62 RADIOLOGY AND NUCLEAR MEDICINE
655003 -- Medical Physics-- Dosimetry
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DOSEMETERS
DOSES
DOSIMETRY
HOURS LIVING RADIOISOTOPES
IMMUNOTHERAPY
IMPLANTS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
LUMINESCENT DOSEMETERS
MEASURING INSTRUMENTS
MEDICINE
MOCKUP
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
PHANTOMS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIATION DOSES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
STRUCTURAL MODELS
THERAPY
THERMOLUMINESCENT DOSEMETERS
THERMOLUMINESCENT DOSIMETRY
YTTRIUM 90
YTTRIUM ISOTOPES