Real-time, in vivo measurement of radiation dose during radioimmunotherapy in mice using a miniature MOSFET dosimeter probe

Journal Article · Wed Mar 01 04:00:00 EST 1995 · Radiation Research

DOI:https://doi.org/10.2307/3579012· OSTI ID:81201

Gladstone, D J; Chin, L M ^[1]

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1. Harvard Medical School, Boston, MA (United States)

This report presents the first real-time measurement of absorbed radiation dose during radioimmunotherapy in mice. Dose rate and total dose at the center of the tumor were measured after administration of {sup 90}Y-labeled antibodies using a miniature metal oxide semiconductor field-effect transistor radiation dosimeter probe which was inserted into the center of the tumor volume. Continuous real-time measurements were made for as long as 23 h after injection of the radiolabeled antibodies. Comparison of the real-time dose-rate measurements with estimates based on the MIRD formalism indicates good agreement. The real-time measurements are further compared to measurements made in a second experiment in which groups of mice were sacrificed at individual times after injection of the same radiolabeled antibodies. The real-time measurements agree well with the measurements in excised tumors. The real-time measurements have greater time resolution and are much more efficient than traditional uptake measurements. 17 refs., 2 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 81201
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 3 Vol. 141; ISSN 0033-7587; ISSN RAREAE
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ANTIBODIES
DOSE RATES
FEASIBILITY STUDIES
INTERNAL IRRADIATION
LABELLED COMPOUNDS
MICE
MOSFET
RADIOIMMUNOTHERAPY
REAL TIME SYSTEMS
SPATIAL DOSE DISTRIBUTIONS
TIME RESOLUTION
YTTRIUM 90