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Sister chromatid exchanges in peripheral lymphocytes after preoperative mammography

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575530· OSTI ID:6395271
 [1]; ;
  1. Gentofte Hospital, Hellerup, Denmark
+ Show Author Affiliations
Examination of sister chromatid exchanges (SCE) in peripheral lymphocytes may be useful for evaluating in vivo exposure to chemical mutagens. In vitro exposure of human lymphocytes to low levels of ionizing radiation has failed to produce increased SCE rates. Scarcity of information about the SCE test system and in vivo exposure to radiation prompted the present study of SCE rates in peripheral lymphocytes in women investigated with mammography prior to operation because of a tumor of the breast. In 64 of a total of 131 women a mammography was performed before the operation. The two groups of patients were identical with respect to age, smoking habits, and incidence of malignancy of the mammary tumors. SCE rates were examined in 30 metaphases from each patient following cultivation of peripheral blood lymphocytes using the BrdU/Giemsa technique.
OSTI ID:
6395271
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 87:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

550400 -- Genetics
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOLS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BIOMEDICAL RADIOGRAPHY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
COLLOIDS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
DNA
DOSES
GLANDS
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMARY GLANDS
MATERIALS
MATHEMATICS
MEDICINE
MUTAGENS
MUTATIONS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIATION DOSES
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RESIDUES
SIDE EFFECTS
SISTER CHROMATID EXCHANGES
SMOKES
SOLS
SOMATIC CELLS
STATISTICS
TOBACCO SMOKES