Exposure to ethylene oxide at work increases sister chromatid exchanges in human peripheral lymphocytes

Journal Article · Fri Mar 11 04:00:00 EST 1983 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.6828851· OSTI ID:5739805

Yager, J W; Hines, C J; Spear, R C

Sister chromatid exchange rates increased significantly in the peripheral lymphocytes of a small group of hospital workers exposed to ethylene oxide for as little as 3.6 minutes per day regularly over a period of months. Results based on breathing zone exposure and task frequency estimates over a 6-month period for 14 workers suggest that sister chromatid exchanges are a sensitive indicator of exposure and that cumulative dose and dose rate are important predictors of sister chromatid exchange response.

• Research Organization: Department of Biomedical and Environmental Health Sciences, School of Public Health, University of California, Berkeley
• OSTI ID: 5739805
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 219:4589; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ETHERS
GENETIC EFFECTS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC OXYGEN COMPOUNDS
INHALATION
INTAKE
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEDICAL PERSONNEL
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PERSONNEL
SISTER CHROMATID EXCHANGES
SOMATIC CELLS