Frequency of sister chromatid exchange in peripheral lymphocytes of male pesticide applicators

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Environmental and Molecular Mutagenesis; (United States)

DOI:https://doi.org/10.1002/em.2850180209· OSTI ID:6052504

Rupa, D S ^[1]; Reddy, P P ^[2]; Sreemannarayana, K ^[3]; Reddi, O S ^[4]

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1. Univ. of California, Riverside (United States)
2. Inst. of Genetics, Hyderabad (India)
3. Sree Venkateswara Eye Clinic, Ongole (India)
4. Inst. of Molecular Immunology and Biotechnology, Hyderabad (India)

In the present study 61 male pesticide applicators who worked in cotton fields and regularly sprayed pesticides such as DDT, BHC, endosulfan, malathion, methyl parathion, phosphamidon, dimethoate, monocrotophos, quinalphos fenvelrate, and cypermethrin were analyzed for sister chromatid exchanges, mitotic index, and cell cycle kinetics in peripheral lymphocytes. Subjects who handled pesticides were non-smokers and teetotalers and the data were compared with the matched control group. Statistical analysis revealed that the frequency of sister chromatid exchanges was significantly higher among the pesticide applicators at all the durations of exposure when compared to controls. Subjects exposed to pesticides also showed cell cycle delay and decrease in mitotic index when compared to the control group.

• OSTI ID: 6052504
• Journal Information: Environmental and Molecular Mutagenesis; (United States), Journal Name: Environmental and Molecular Mutagenesis; (United States) Vol. 18:2; ISSN 0893-6692; ISSN EMMUE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
ASIA
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL PROLIFERATION
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DDT
DEVELOPING COUNTRIES
ESTERS
INDIA
INSECTICIDES
LEUKOCYTES
LYMPHOCYTES
MALES
MAMMALS
MAN
MATERIALS
MEN
MITOTIC INDEX
MUTATION FREQUENCY
MUTATIONS
OCCUPATIONAL EXPOSURE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARATHION
PESTICIDES
PRIMATES
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
THIOPHOSPHORIC ACID ESTERS
VERTEBRATES