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Effects of chronic exposure to 2, 3, 7, 8,-tetrachlorodibenzo-p-dioxin on sister chromatid exchange levels in peripheral lymphocytes of the rhesus monkey

Technical Report ·
OSTI ID:7070257
; ; ;
Frequencies of sister chromatid exchanges and chromosomal aberrations were examined in peripheral lymphocytes of Rhesus monkeys that had been fed a diet containing 25 parts per trillion 2,3,7,8-tetrachlorodibenzo-p-dioxin for a period of 4 years. When compared to non-exposed control animals, no significant differences were noted for either of these cytogenetic end points. In addition, there was not a significant difference in sister chromatid exchange response to a challenge dose of mitomycin C in cells from 2,3,7,8-tetrachlorodibenzo-p-dioxin exposed animals compared to controls. The results confirm the lack of genotoxic effects associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.
Research Organization:
Johns Hopkins Oncology Center, Baltimore, MD (USA). Radiobiology Lab.
OSTI ID:
7070257
Report Number(s):
PB-88-215264/XAB
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
DIOXIN
HAZARDOUS MATERIALS
HETEROCYCLIC COMPOUNDS
LABORATORY ANIMALS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MONKEYS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PRIMATES
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
VERTEBRATES