Sister chromatid exchange in normal adults long after thymus irradiation
Journal Article
·
· Invest. Radiol.; (United States)
Chromosomal breaks are seen in the peripheral blood lymphocytes of irradiated patients long after the original exposure. This is confirmed in our present investigation. We found 141 (20%)chromosomal breaks in 707 metaphases from 18 thymus-irradiated patients and only 26 (6.3%) in 410 metaphases from six of their normal siblings. Sister chromatid exchange (SCE) has been used to test the mutagen-carcinogen agents. However, radiation, a well-known mutagen-carcinogen agent, has no effect upon SCE. This suggests that the SCE and chromosomal breakage mechanisms may be quite different; study of them may help us to understand chromosomal breakage and healing.
- OSTI ID:
- 5762389
- Journal Information:
- Invest. Radiol.; (United States), Journal Name: Invest. Radiol.; (United States) Vol. 15:4; ISSN INVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DELAYED RADIATION EFFECTS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MATERIALS
MEDICINE
MUTATIONS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RECOVERY
REPAIR
SIDE EFFECTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
THERAPY
THYMUS
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DELAYED RADIATION EFFECTS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MATERIALS
MEDICINE
MUTATIONS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RECOVERY
REPAIR
SIDE EFFECTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
THERAPY
THYMUS