Gallium-67 uptake by the liver: studies using isolated rat hepatocytes and perfused livers

Journal Article · Mon Oct 01 00:00:00 EDT 1984 · J. Nucl. Med.; (United States)

OSTI ID:6385373

Scheffel, U; Wagner, Jr, H N; Frazier, J M; Tsan, M F

The authors studied the hepatic uptake of carrier-free Ga-67 using isolated rat hepatocytes and perfused livers. The results indicate that: (a) the liver can take up Ga-67 and secrete it into the bile, even in the absence of transferrin; (b) transferrin inhibits hepatic uptake of Ga-67 and its biliary excretion; and (c) iron deficiency markedly enhances hepatic uptake of Ga-67.

• Research Organization: Johns Hopkins Medical Institutions, Baltimore, MD
• OSTI ID: 6385373
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:10; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CARBOXYLIC ACID SALTS
CITRATES
DATA
DIGESTIVE SYSTEM
ELEMENTS
EXPERIMENTAL DATA
GALLIUM
GLANDS
GLOBULINS
GLOBULINS-BETA
GLUCOPROTEINS
INFORMATION
IRON
LACTOFERRIN
LIVER
LIVER CELLS
MAMMALS
METALLOPROTEINS
METALS
NUMERICAL DATA
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PERFUSED TISSUES
PROTEINS
RADIONUCLIDE KINETICS
RATS
RODENTS
SACCHARIDES
SOMATIC CELLS
TISSUES
TRANSFERRIN
TRANSITION ELEMENTS
VERTEBRATES