Source of fecal gallium--clinical implications: concise communication. [Gallium-67 kinetics in rats]

Journal Article · Wed Nov 01 04:00:00 EST 1978 · J. Nucl. Med.; (United States)

OSTI ID:6201933

Taylor, A; Chafetz, N; Hollenbeck, J; Hooser, W

Bowel preparation before gallium-67 scanning often conists of cathartics, enemas, and a liquid or low-residue diet. Since human bile has approximately one-third the gallium concentration of the liver, the diet is presumably designed to minimize biliary excretion of gallium into the gut. To determine the actual biliary contribution to fecal gallium, the bile ducts of 15 rats were ligated and severed. Following the i.v. injection of Ga-67 citrate, the 72-hr fecal excretion of gallium was compared with that of 15 control rats with only a sham operation. Tissue distribution studies were also performed, and an additional 14 rats were gavaged with Ga-67 citrate to assess intestinal absorption. The organ distribution of gallium was similar in both groups and there was no appreciable intestinal absorption. The 72-hr fecal excretion of gallium in the control animals was not significantly different from that in the group with ligated bile duct: 13.1% compared with 12.9%, respectively. The data suggest that gallium reaches the feces primarily through the bowel mucosa rather than by biliary excretion, and for that reason it is probably unnecessary to deprive a patient of solid food. Furthermore, a liquid or low-residue diet is unlikely to facilitate gallium transit through the bowel.

• Research Organization: Univ. of California, San Diego
• OSTI ID: 6201933
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:11; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CARBOXYLIC ACID SALTS
CITRATES
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIET
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
FECES
GALLIUM 67
GALLIUM COMPOUNDS
GALLIUM ISOTOPES
GASTROINTESTINAL TRACT
INGESTION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
INTRAVENOUS INJECTION
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
METABOLISM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
SCINTISCANNING
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
WASTES