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Source of Gallium-67 in gastrointestinal contents: concise communication

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6985371
; ; ;

The sources of Ga-67 in gastrointestinal (GI) contents, and factors affecting its secretion were studied in rats. To prevent loss of fecal Ga-67, the anus was sutured before intravenous injection of Ga-67 citrate. Secretion of Ga-67 into the contents of the GI tract was rapid, 3, 6, and 9% of the injected dose were secreted at 1, 6, and 24 hr after injection, respectively. In contrast, Ga-67 concentration in the GI tissues remained relatively constant throughout this period. Analysis of Ga-67 contents of various parts of the GI tract revealed that small intestine is its major source, contributing 60% while the bile contributes 20%, large intestine 10%, esophagus and stomach 10%. Feeding had no effect on the Ga-67 secretion into GI contents. In contrast, the serum unbound iron-binding capacity (UIBC) played an important role in the GI secretion of Ga-67; reducing the serum UIBC reduced the Ga-67 secretion into GI contents.

Research Organization:
Johns Hopkins Medical Institutions, Baltimore, MD
OSTI ID:
6985371
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:12; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BILE
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACID ESTERS
CITRIC ACID ESTERS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ESOPHAGUS
ESTERS
GALLIUM 67
GALLIUM ISOTOPES
GASTROINTESTINAL TRACT
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINES
INTRAVENOUS INJECTION
ISOTOPES
LARGE INTESTINE
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SCINTISCANNING
SECRETION
SIDE EFFECTS
SMALL INTESTINE
STOMACH
TISSUE DISTRIBUTION
USES
VERTEBRATES