Metabolism of 1-(14C)nitropyrene in isolated perfused rat livers
Journal Article
·
· Toxicol. Appl. Pharmacol.; (United States)
1-Nitropyrene (1-NP), a constituent of diesel exhaust, is carcinogenic to rats and is a bacterial and mammalian mutagen. Biliary and fecal excretion of 1-NP metabolites are the major routes of excretion in rats, suggesting that hepatic metabolism plays a dominant role in determining the biological fate of 1-NP. The purpose of this investigation was to quantitate 1-(14C)NP metabolites formed in isolated perfused rat livers and excreted in bile from rats. Perfused rat livers displa
- Research Organization:
- Inhalation Toxicology Research Inst., Albuquerque, NM
- OSTI ID:
- 6300958
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 75:3; ISSN TXAPA
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:5391966