Mechanisms for radiation damage in DNA, Progress report, November 1, 1977--October 31, 1978. [Gamma radiation]

Technical Report · Thu Jun 01 04:00:00 EDT 1978

DOI:https://doi.org/10.2172/6371248· OSTI ID:6371248

Sevilla, M D

In this project we have proposed several mechanisms for radiation damage to DNA constituents and DNA, and have detailed a series of experiments utilizing electron spin resonance spectrometry to test the proposed mechanisms. In the past we have concentrated chiefly on the direct affect of radiation on DNA. We are currently investigating systems of DNA constituents and peptides which may shed light on indirect effects. Studies which we have completed during the past year are: ..pi..-cation radicals in DNA and dinucleoside phosphates, and conformational effects on the ESR Spectra of amino acids and peptides. Studies of ..gamma..-Irradiated Peptide Solutions at 77/sup 0/K, and studies of spin transfer in ..gamma..-irradiated nucleoside--peptide solutions were also conducted.

• Research Organization: Oakland Univ., Rochester, MI (USA)
• DOE Contract Number: EY-76-S-02-2364
• OSTI ID: 6371248
• Report Number(s): COO-2364-15
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBOXYLIC ACIDS
DNA
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
GAMMA RADIATION
INJURIES
IONIZING RADIATIONS
KINETICS
MAGNETIC RESONANCE
MEASURING INSTRUMENTS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PEPTIDES
PROTEINS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADICALS
REACTION KINETICS
RESONANCE
RIBOSIDES
SPECTRA
SPECTROMETERS