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Mechanisms for radiation damage in DNA. Progress report, November 1, 1978-October 31, 1979

Technical Report ·
DOI:https://doi.org/10.2172/5793741· OSTI ID:5793741
Several mechanisms for radiation damage to DNA constituents and DNA are proposed, and a series of experiments utilizing electron spin resonance spectrometry to test the proposed mechanisms are detailed. In the past we have concentrated chiefly on the direct affect of radiation on DNA. We are currently investigating systems of DNA constituents and peptides which may shed light on indirect effects. Studies which have been completed during the past year include: (1) studies of ..gamma..-irradiated N-acetyl amino acids and peptide solutions at 77/sup 0/K; and (2) studies of barriers to hindered rotation in peptide radicals. Studies in which progress has been made in this past year include: (1) ..pi.. cations produced in DNA bases by hydroxyl radical attack; and (2) studies of spin transfer in ..gamma..-Irradiated nucleoside-peptide solutions. These studies have shown that: (1) frozen aqueous solutions provide a suitable matrix for ..gamma.. irradiation studies; (2) ..gamma..-irradiated peptides in frozen aqueous solutions follow chemistry expected from previous studies; and (3) ..pi.. cations of DNA base can be produced by hydroxyl radical attack.
Research Organization:
Oakland Univ., Rochester, MI (USA)
DOE Contract Number:
EY-76-S-02-2364
OSTI ID:
5793741
Report Number(s):
COO-2364-16
Country of Publication:
United States
Language:
English

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Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400500 -- Photochemistry
400600* -- Radiation Chemistry
550200 -- Biochemistry
560111 -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CHARGED PARTICLES
CHARGED-PARTICLE REACTIONS
CHEMICAL RADIATION EFFECTS
CHEMISTRY
DISPERSIONS
DNA
ELECTROMAGNETIC RADIATION
ELECTRON REACTIONS
ENERGY LEVELS
EXCITED STATES
HYDROXYL RADICALS
IONIZATION
IONIZING RADIATIONS
IONS
LEPTON REACTIONS
MAGNETIC RESONANCE
MIXTURES
MORPHOLOGICAL CHANGES
NUCLEAR REACTIONS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PEPTIDES
PHOTOIONIZATION
PROTEINS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOINDUCTION
RESONANCE
RIBOSIDES
ROTATIONAL STATES
SOLUTIONS
SPIN EXCHANGE
ULTRASTRUCTURAL CHANGES
YIELDS