Human teratogenic and mutagenic markers in monitoring about point sources of pollution

Journal Article · Mon Jun 01 04:00:00 EDT 1981 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(81)90089-X· OSTI ID:6358627

Hook, E B

For most pollutants a full range of short-term adverse reproductive outcomes should be considered as possible markers in monitoring populations. These include sex ratio, birthweight, intrauterine growth retardations, neonatal motality, birth defects manifest at birth or very shortly thereafter, embryonic and fetal deaths (EFD), germinal chromosome abnormalities in EFD and in livebirths, specific locus mutations detectable at birth, and indicators of somatic mutation including chromosome breakage and sister chromatid exchange. It is suggested (in the absence of a defined expected effect) that the highest priority be given to study of rates of EFD and of somatic chromosome rearrangement. Where possible, data on reproductive and mutagenic outcomes in the potential target population should be sought systematically before a putative pollution source comes into operation. Reference data on human mutagenic and teratogenic outcomes are presented.

• Research Organization: New York State Dept. of Health, Albany
• OSTI ID: 6358627
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 25:7; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
552000 -- Public Health
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
CHROMOSOMAL ABERRATIONS
EMBRYOS
GENETIC EFFECTS
MEDICAL SURVEILLANCE
MORTALITY
MUTAGENESIS
MUTATIONS
POINT POLLUTANT SOURCES
POLLUTION SOURCES
REPRODUCTION
SISTER CHROMATID EXCHANGES
SURVEILLANCE
TERATOGENESIS