Biologic monitoring of exposure to chemical mutagens in the occupational environment
Occupational exposure to chemical mutagens can be monitored by measuring the chemical interaction that occurs between the exposing agent and biologic macro-molecules. Such interaction is detectable in the body fluids as adducts of, e.g., DNA or glutathione. The mutagenic compounds or their metabolites can also be measured from urine samples, by use of bacterial mutagenicity assays. Much basic research is still needed before these methodologies are applicable for routine monitoring. At present, cytogenetic approaches appear to be nearest to routine surveillance in detecting early biologic effects in exposed humans. Studies on structural chromosome aberrations or sister chromatid exchanges (SCEs) in peripheral blood lymphocytes obviously detect different molecular injuries, and the results from in vivo occupational exposures do not necessarily correlate. Somatic chromosome damage should always be considered a warning sign of potentially adverse effects, and such damage should lead to decreased exposure to the causative agent.
- Research Organization:
- Institute of Occupational Health, Department of Industrial Hygiene and Toxicology, Helsinki, Finland
- OSTI ID:
- 6851605
- Journal Information:
- Teratog., Carcinog., Mutagen.; (United States), Journal Name: Teratog., Carcinog., Mutagen.; (United States) Vol. 2:2; ISSN TCMUD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cytogenetic surveillance of workers exposed to genotoxic chemicals: Preliminary experiences from a prospective cancer study in a cytogenetic cohort
Mutagenic monitoring of workplace and workers. Final report
Related Subjects
570000 -- Health & Safety
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
ANIMAL CELLS
BACTERIA
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DNA
DRUGS
GLUTATHIONE
INDUSTRIAL MEDICINE
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEDICINE
METABOLITES
MICROORGANISMS
MONITORING
MUTAGEN SCREENING
MUTAGENS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PEPTIDES
PERSONNEL
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
SCREENING
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
URINE
WASTES