Mutagenic monitoring of workplace and workers. Final report

Technical Report · Mon Dec 01 04:00:00 EST 1986

OSTI ID:5871904

In efforts to safeguard employees against occupational exposure to potential genotoxic agents, various assay systems were devised and tested. Due to the fact that short-term genotoxicity studies can provide information regarding not only potential genetic hazards, but carcinogenic and teratogenic hazards as well, the establishment of these assay systems may be extremely important. Brief descriptions were offered of several studies in this area. These included: mutagenicity studies of air particles, volatile compounds and complex mixtures taken from workplace samples; development and validation of an in-situ assay system to detect airborne mutagenic agents in the workplace; the human cytogenetic assay system which has both sister chromatid exchange and chromosome aberration endpoints; the development of a bacterial forward mutation assay system using the new tester strain (SV-50) for the Salmonella arabinose resistant-forward mutation assay system; an evaluation of a urine mutagenesis assay system that has been used to determine whether workers were exposed to mutagenic agents.

• Research Organization: National Inst. for Occupational Safety and Health, Cincinnati, OH (USA)
• OSTI ID: 5871904
• Report Number(s): PB-87-223202/XAB
• Country of Publication: United States
• Language: English

Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
552000* -- Public Health
99 GENERAL AND MISCELLANEOUS
AIR POLLUTION MONITORING
CARCINOGENS
CELL CULTURES
HAZARDOUS MATERIALS
INDUSTRIAL MEDICINE
INSPECTION
MATERIALS
MEDICINE
MUTAGENS
OCCUPATIONAL EXPOSURE
TERATOGENS
TOXIC MATERIALS
TOXICITY