Correlative genotoxicity studies of airborne particles in Salmonella typhimurium and cultured human lymphocytes
Journal Article
·
· Environ. Mutagen.; (United States)
The acetone extracts of ambient air particulates collected locally were tested for their capacity to induce sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) in human lymphocytes, and to induce gene mutations (GMs) in Salmonella typhimurium. The extracts caused dose-related clastogenic/mutagenic responses in all three assay systems. With the same concentration, it seems that the Ames Salmonella/microsomal assay with TA98 gave the highest, and the chromosomal aberration assay with human lymphocytes the lowest, mutagenic/clastogenic responses, respectively. Because high frequencies of SCEs were induced by solvent extracts of airborne particles, this study further indicated the usefulness of SCE assay in human lymphocytes for genotoxicity studies of airborne particles.
- Research Organization:
- West Virginia Univ., Morgantown
- OSTI ID:
- 6220444
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 6:4; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMAL CELLS
ANIMALS
BACTERIA
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DATA
EXPERIMENTAL DATA
EXTRACTION
GENE MUTATIONS
GENETIC EFFECTS
IN VITRO
INFORMATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MICROORGANISMS
MUTATIONS
NUMERICAL DATA
PARTICLES
PARTICULATES
POLLUTION
PRIMATES
SALMONELLA
SALMONELLA TYPHIMURIUM
SEPARATION PROCESSES
SISTER CHROMATID EXCHANGES
SOLVENT EXTRACTION
SOMATIC CELLS
VERTEBRATES
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMAL CELLS
ANIMALS
BACTERIA
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DATA
EXPERIMENTAL DATA
EXTRACTION
GENE MUTATIONS
GENETIC EFFECTS
IN VITRO
INFORMATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MICROORGANISMS
MUTATIONS
NUMERICAL DATA
PARTICLES
PARTICULATES
POLLUTION
PRIMATES
SALMONELLA
SALMONELLA TYPHIMURIUM
SEPARATION PROCESSES
SISTER CHROMATID EXCHANGES
SOLVENT EXTRACTION
SOMATIC CELLS
VERTEBRATES