Comparison of the genotoxic activities of extracts from ambient and forest fire polluted air. [Humans]

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860040106· OSTI ID:5474249

Viau, C J ^[1]; Lockard, J M; Enoch, H G; Sabharwal, P S

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1. Univ. of Kentucky, Lexington

The genotoxicity of airborne organic particles from forest fire smoke was compared to that from nonsmoky (ambient) urban air using the Salmonella reversion assay and the sister chromatid exchange (SCE) assay in cultured human lymphocytes. Salmonella strains TA98 and TA100 were used with and without the addition of Aroclor-induced rat liver homogenate (S9). Each sample induced dose-related increases in mutagenicity and SCE. However, on the basis of the volume of air sampled, the smoke-filled air induced 12 to 14 times more bacterial reversions in TA 100 and 16-38 times more reversion in TA98 than ambient air. Similarly, on a volume basis smoky air induced 43 times more SCE in human lymphocytes than did ambient air. The results indicate that the increased mutagenicity was due not only to the heavier particulate load of the air, but also to the increased specific mutagenicity of the particles.

• OSTI ID: 5474249
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 4:1; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ANIMAL CELLS
BACTERIA
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
COLLOIDS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DISPERSIONS
FIRES
FORESTS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
METABOLIC ACTIVATION
MICROORGANISMS
MUTAGEN SCREENING
MUTANTS
MUTATIONS
PARTICLES
PARTICULATES
POLLUTION
RESIDUES
REVERTANTS
SCREENING
SISTER CHROMATID EXCHANGES
SMOKES
SOLS
SOMATIC CELLS
URBAN AREAS