Genotoxicity studies of methyl isocyanate in Salmonella, Drosophila, and cultured Chinese hamster ovary cells
Journal Article
·
· Environ. Mutagen.; (United States)
The genotoxic effects of methyl isocyanate (MIC) were investigated using four short-term tests: the Salmonella reversion assay (Ames test), the Drosophila sex-linked recessive lethal assay, and the sister chromatic exchange (SCE) and chromosomal aberration assays in cultured Chinese hamster ovary (CHO) cells. No evidence was found for the induction of mutations in either Salmonella or Drosophila. MIC did, however, induce SCEs and chromosomal aberrations in CHO cells both in the presence and absence of Aroclor-induced rat liver S-9.
- Research Organization:
- National Institute of Environmental Health Sciences, Research Triangle Park, NC
- OSTI ID:
- 6698851
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 9:1; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARTHROPODS
BACTERIA
BIOLOGICAL EFFECTS
BODY
CHO CELLS
CHROMOSOMAL ABERRATIONS
DIGESTIVE SYSTEM
DIPTERA
DROSOPHILA
FLIES
FRUIT FLIES
GENETIC EFFECTS
GLANDS
INSECTS
INVERTEBRATES
ISOCYANATES
LIVER
MAMMALS
METABOLIC ACTIVATION
MICROORGANISMS
MUTAGEN SCREENING
MUTATIONS
ORGANS
RATS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SISTER CHROMATID EXCHANGES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARTHROPODS
BACTERIA
BIOLOGICAL EFFECTS
BODY
CHO CELLS
CHROMOSOMAL ABERRATIONS
DIGESTIVE SYSTEM
DIPTERA
DROSOPHILA
FLIES
FRUIT FLIES
GENETIC EFFECTS
GLANDS
INSECTS
INVERTEBRATES
ISOCYANATES
LIVER
MAMMALS
METABOLIC ACTIVATION
MICROORGANISMS
MUTAGEN SCREENING
MUTATIONS
ORGANS
RATS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SISTER CHROMATID EXCHANGES
VERTEBRATES