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Amino acid distribution and metabolism in pituitary adenomas using positron emission tomography with D-(/sup 11/C)methionine and L-(/sup 11/C)methionine

Journal Article · · J. Comput. Assist. Tomogr.; (United States)
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Four patients with hormonally inactive pituitary adenomas were examined with positron emission tomography (PET) after injection, during different examinations, of L-(methyl-/sup 11/C)methionine and D-(methyl-/sup 11/C)methionine, respectively. After the rapid distribution phase, the enantiomer L-(/sup 11/C)methionine, which is metabolically active, showed a considerable continuous irreversible trapping attributed to amino acid metabolism. The stereoisomer D-(/sup 11/C)methionine, which does not participate in protein synthesis, showed a rapid distribution within the whole adenoma tissue, with a distribution space on the order of 100%. A minimal irreversible trapping was observed which could be explained by technical factors. It is concluded that PET using the two enantiomers allows a separation of passive distribution and metabolism, and that L-(/sup 11/C)methionine can be used for in vivo quantitative studies of amino acid metabolism of pituitary adenomas.

Research Organization:
Univ. Hospital, Uppsala, Sweden
OSTI ID:
6354817
Journal Information:
J. Comput. Assist. Tomogr.; (United States), Journal Name: J. Comput. Assist. Tomogr.; (United States) Vol. 3; ISSN JCATD
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOMAS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
ISOTOPES
LIGHT NUCLEI
LIPOTROPIC FACTORS
METABOLISM
METHIONINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
PITUITARY GLAND
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
TISSUE DISTRIBUTION
TOMOGRAPHY