Rapid decrease in amino acid metabolism in prolactin-secreting pituitary adenomas after bromocriptine treatment: a PET study
Four patients with prolactin-secreting pituitary adenomas were examined with positron emission tomography using L-(/sup 11/C)methionine to monitor the effect of dopamine agonist treatment on the amino acid metabolism in the tumors. Within the first few hours after intramuscular injection of bromocriptine retard (50 mg) the amino acid metabolism decreased by 40%. Two of the patients were reexamined 7 and 9 days later and showed a 70% reduction in the metabolism of the adenomas. This metabolic effect was later accompanied by significant tumor shrinkage in all adenomas. It is suggested that bromocriptine has a general and rapid effect on the protein synthesis of the prolactin-secreting pituitary adenoma cells.
- Research Organization:
- Univ. Hospital, Uppsala, Sweden
- OSTI ID:
- 5851183
- Journal Information:
- J. Comput. Assist. Tomogr.; (United States), Journal Name: J. Comput. Assist. Tomogr.; (United States) Vol. 11:5; ISSN JCATD
- Country of Publication:
- United States
- Language:
- English
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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOMAS
AMINO ACIDS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EFFICIENCY
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
GONADOTROPINS
HORMONES
ISOTOPES
LIGHT NUCLEI
LIPOTROPIC FACTORS
LTH
METABOLISM
METHIONINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
TOMOGRAPHY