Dynamic study of supratentorial gliomas with L-methyl-/sup 11/C-methionine and positron emission tomography

Journal Article · Mon Jul 01 00:00:00 EDT 1985 · AJNR, Am. J. Neuroradiol.; (United States)

OSTI ID:5022357

Lilja, A; Bergstroem, K H; Hartvig, P; Spaennare, B H; Halldin, C; Lundqvist, H; Langstrom, B

The regional kinetics of intravenously injected L-methyl-/sup 11/C-methionine (/sup 11/C-L-methionine) in the brain was investigated by positron emission tomography (PET) in 14 patients with gliomas. In both tumor and unaffected brain the tracer uptake reached a nearly constant level in 5 min or less. The ratio between the uptake of /sup 11/C-L-methionine by high-grade tumors and the uptake by unaffected brain was 1.9-4.8. In two cases of low-grade astrocytoma the ratio was 0.8-1.0. High uptakes of /sup 11/C-L-methionine occurred in gliomas even in the absence of blood-brain barrier defects as observed by other methods. This indicates that besides active transport of amino acid, a larger extracellular space in tumor as compared with unaffected brain tissue may also contribute to the increased uptake of /sup 11/C-L-methionine--derived radioactivity. In some patients delineation of the tumors was improved by use of PET with /sup 11/C-L-methionine as compared with computed tomography, angiography, and, in some instances, PET with /sup 68/Ga-EDTA. PET with /sup 11/C-L-methionine permits better evaluation of the tumor extent and may affect preoperative grading.

• Research Organization: Uppsala Univ., Sweden
• OSTI ID: 5022357
• Journal Information: AJNR, Am. J. Neuroradiol.; (United States), Journal Name: AJNR, Am. J. Neuroradiol.; (United States) Vol. 4; ISSN AAJND
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANTILEPTONS
ANTIMATTER
ANTIPARTICLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EDTA
ELEMENTARY PARTICLES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FERMIONS
GALLIUM 68
GALLIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LEPTONS
LIGHT NUCLEI
LIPOTROPIC FACTORS
METHIONINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
POSITRONS
RADIOISOTOPES
REACTION KINETICS
TOMOGRAPHY
TRACER TECHNIQUES
UPTAKE