Clinical evaluation of thallium-201 SPECT for the detection and differentiation of gliomas: A comparative study with C-11 methionine and F-18 FDG PET
- Kyushu Univ., Fukuoka (Japan); and others
The aim of this study is to evaluate thallium (Tl)-SPECT in the detection and differentiation of gliomas and then to compare it with the results of methionine (MET)-PET and FDG-PET. We examined 8 patients with gliomas including 3 patients with astrocytoma grade-II, 3 with anaplastic astrocytoma grade-III, 1 with glioblastoma and 1 with malignant oligodendroglioma. A glioblastoma and a malignant oligodendroglioma were grouped together as highly malignant gliomas. The Tl-SPECT images were obtained by GCA9300A 15 minutes after the administration of 148 MBq of thallium. The SPECT images were graded as negative, positive and intensely positive according to the focal thallium uptake in the tumor. Both the MET-PET and FDG-pet were examined by HEADTOME III one hour after the administration of 148-851 MBq of radiopharmaceuticals. Thereafter the standard uptake value (SUV) of MET and FDG were determined. One out of the 3 patients with astrocytoma grade-II and 3 out of the 3 with anaplastic astroycytoma grade-III were positive on Tl-SPECT. Two out of the 2 patients with highly malignant gliomas were intensely positive on Tl-SPECT. The mean SUV of MET for astrocytoma grade-II with negative Tl-SPECT was 0.92, for astrocytoma grade-II with positive Tl-SPECT it was 1.57, for anaplastic astrocytoma grade-III it was 3.02 and for highly malignant glioma it was 3.55. On the other hand, those of FDG were 3.02,4.41,2.25 and 3.70, respectively. In conclusion, Tl-SPECT was found to be as sensitive as MET-PET for detecting gliomas. The grade of Tl accumulation and the SUV of MET demonstrated a positive correlation with the histological grade of gliomas.
- OSTI ID:
- 197918
- Report Number(s):
- CONF-940605--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN JNMEAQ; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
Similar Records
Can brain thallium 201 SPECT substitute for F-18-FDG PET in detecting recurrent brain tumor in the presence of radiation necrosis; correlation with biopsy/surgery results
Differentiating histologic malignancy of primary brain tumors: Pentavalent Technetium-99m-DMSA