Neonatal irradiation nephropathy in the growing dog. II. Plasma renin activity and arterial pressure following neonatal, sublethal, whole-body irradiation. [. gamma. rays; beagles]

Journal Article · Sun Apr 01 04:00:00 EST 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575008· OSTI ID:6311916

Wilke, W L; Jaenke, R S; Phemister, R D

Sixty beagles were used to study the effects of exposure to 330 R /sup 60/Co ..gamma.. radiation (bilateral, whole-body) at 2 days of age on plasma renin activity (PRA) and arterial pressure during development. Mean PRA values were found to be not significantly different in irradiated and nonirradiated dogs at 10 and 21 days of age and equivalent between 50 and 200 days of age. On the basis of prior demonstrations of reductions in nephron numbers and renal mass following similar irradiation, these data indicate inappropriately high PRA values in irradiated animals. A small number of irradiated animals had high PRA values between 50 and 200 days of age and were significant outliers as compared to other irradiated animals (P < 0.05). These outliers also had noticeably more severe morphological lesions as compared to other irradiated animals. Irradiated animals had a significantly higher mean arterial pressure at 125 days of age (P < 0.05) but were not significantly different from nonirradiated animals 50 to 200 days of age. It is proposed that irradiated animals attain mature levels of arterial pressure sooner than nonirradiated animals. In addition, a smaller number of 200-day-old irradiated animals had values for mean arterial pressure which were over two standard deviations higher than the value for nonirradiated animals. These elevations in arterial pressure were not consistently associated with elevations in PRA. The inappropriately high PRA in irradiated animals may contribute to the development of chronic renal failure in these animals.

• Research Organization: Colorado State Univ., Fort Collins
• OSTI ID: 6311916
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 78:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTERIES
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD PLASMA
BLOOD PRESSURE
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COBALT 60
COBALT ISOTOPES
DATA
DATA FORMS
DISEASES
DOGS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
ETIOLOGY
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
HYDROLASES
HYPERTENSION
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NEONATES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
PEPTIDE HYDROLASES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RENIN
SUBLETHAL IRRADIATION
SYMPTOMS
UROGENITAL SYSTEM DISEASES
VASCULAR DISEASES
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES