Radiation injury in the neonatal canine kidney. I. Pathogenesis

Journal Article · Tue Nov 01 04:00:00 EST 1977 · Lab. Invest.; (United States)

OSTI ID:6880124

Eisenbrandt, D L; Phemister, R D

The effects of radiation on the developing canine kidney were investigated. Beagles were exposed to 330 R /sup 60/Co gamma-radiation on the 2nd postnatal day of life. The kidneys were examined at 2 days (6 hours after irradiation), 4, 8, 14, 22, 70, and 200 days of age with qualitative and quantitative light microscopy and scanning electron microscopy. The primary result of the radiation injury was a failure to form the normal number of nephrons. The kidneys of irradiated dogs had 42 percent fewer nephrons (260,000) than the control dogs (445,000). In addition, extensive damage to forming nephrons produced dysplastic renal corpuscles and other corpuscles which were arrested in their development. Three mechanisms of radiation injury were identified. First, there was extensive mitosis-linked cell death in the nephrogenic zone. Second, mitotic delay resulted in only one-fifth of the normal mitotic activity in the nephrogenic zone through 2 days postirradiation. Third, there was an immediate and permanent cessation of nephron formation. The extensive injury in the outer renal cortex was compounded by the development of intercapillary glomerulosclerosis in some middle and inner cortical corpuscles by 200 days of age.

• Research Organization: Colorado State Univ., Fort Collins
• OSTI ID: 6880124
• Journal Information: Lab. Invest.; (United States), Journal Name: Lab. Invest.; (United States) Vol. 37:5; ISSN LAINA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL KILLING
DISEASES
DOGS
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
GAMMA RADIATION
INJURIES
IONIZING RADIATIONS
KIDNEYS
MAMMALS
MICROSCOPY
MITOTIC DELAY
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
TIME DEPENDENCE
VERTEBRATES