Radiation injury in the neonatal canine kidney. II. Quantitative morphology

Journal Article · Wed Mar 01 04:00:00 EST 1978 · Lab. Invest.; (United States)

OSTI ID:6737396

Eisenbrandt, D L; Phemister, R D

Quantitative morphology was used to investigate injury induced in the developing canine kidney by ionizing radiation. Irradiation at 2 days of age destroyed nephrogenic tissue in the outer renal cortex and significantly reduced kidney weight and volume through 70 days of age. However, as early as 14 days of age and continuing through 200 days of age, hypertrophy was demonstrated in the surviving middle and inner cortical nephrons of these kidneys. Both corpuscular and tubular components of the nephrons grew at an accelerated rate as compared to controls. The corpuscular volume per nephron increased 559 percent in irradiated dogs and only 249 percent in controls from 14 to 200 days of age. The tubular volume per nephron increased 519 percent in irradiated dogs and 303 percent in controls during the same period. As a result of the compensatory growth in individual nephrons, the kidneys of irradiated dogs at 200 days of age were as large as the controls when compared on the basis of body weight. The extensive hypertrophy is associated with accelerated development of intercapillary glomerulosclerosis in dogs irradiated around the time of birth.

• Research Organization: Colorado State Univ., Fort Collins
• OSTI ID: 6737396
• Journal Information: Lab. Invest.; (United States), Journal Name: Lab. Invest.; (United States) Vol. 38:3; ISSN LAINA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COBALT 60
COBALT ISOTOPES
DISEASES
DOGS
DOSES
GLOMERULI
HYPERTROPHY
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MINUTES LIVING RADIOISOTOPES
MORPHOLOGICAL CHANGES
NEONATES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES