Neonatal irradiation nephropathy in the growing dog. I. Renal morphological and functional adaptations following neonatal, sublethal, whole-body irradiation. [. gamma. rays; beagles]

Journal Article · Sun Apr 01 04:00:00 EST 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575007· OSTI ID:6311935

Wilke, W L; Phemister, R D; Jaenke, R S

Sixty beagles were used to study the effects of exposure to 330 R /sup 60/Co ..gamma.. radiation (bilateral, whole-body) at 2 days of age on renal functional and morphological development in the growing dog. A significant deficit in grams kidney per kilogram body weight was found in irradiated dogs at 50 days of age (P < 0.05), but not at 125 or 200 days of age. Glomerular filtration rate (GFR) per kilogram body weight and GFR per gram kidney were not significantly different between irradiated and nonirradiated dogs at 50, 125, or 200 days of age, but blood urea nitrogen (BUN) was significantly elevated in irradiated dogs throughout this period (P < 0.05). The fractional distribution of intracortical renal blood flow, as determined by radiolabeled microspheres, to the outermost cortex was found to be reduced in irradiated animals at all ages evaluated (P < 0.05). The fractional blood flow to the outermost renal cortex was negatively correlated with BUN in both irradiated (P < 0.05) and nonirradiated (P < 0.05) animals. Based on prior demonstrations of reductions in nephron numbers following similar irradiation, these data indicate increases in mean single nephron GFR and nephronal hypertrophy in the kidneys of the neonatally irradiated dog. The renal functional and morphological adaptations are sufficient to maintain adequate renal function in growing, neonatally irradiated dogs. The BUN elevations in irradiated dogs are believed to be related to changes in intracortical renal blood flow, rather than indicating renal insufficiency. The possible importance of the functional and morphological adaptations to the subsequent development of chronic renal failure in neonatally irradiated animals is discussed.

• Research Organization: Colorado State Univ., Fort Collins
• OSTI ID: 6311935
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 78:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550801 -- Morphology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ADAPTATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FLOW
BODY
COBALT 60
COBALT ISOTOPES
DATA
DATA FORMS
DISEASES
DOGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
GLOMERULI
HYPERTROPHY
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MINUTES LIVING RADIOISOTOPES
MORPHOLOGY
NEONATES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PHYSIOLOGY
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
SEPARATION PROCESSES
SUBLETHAL IRRADIATION
ULTRAFILTRATION
VERTEBRATES
WEIGHT
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES