Glutathione peroxidase activity of animal tissues as an index of selenium status

Conference · Wed Jan 01 04:00:00 EST 1975 · Trace Subst. Environ. Health; (United States)

OSTI ID:6298518

Hoekstra, W G

This paper reviews briefly the responsiveness of glutathione peroxidase activity in tissues of animals to dietary Se intake. The body components in which glutathione peroxidase has been reported to be most dramatically affected by prolonged Se deficiency include blood plasma, liver, heart, lungs, stomach mucosa, skeletal muscle and eye lens. Components showing moderate effects include erythrocytes, kidney and adrenal glands. The organs least affected are testis and brain. Because of ready sampling access, blood components offer the most useful index. Studies with sheep have demonstrated a close relationship of erythrocyte glutathione peroxidase to Se intakes ranging from deficient to more than adequate levels. Plasma glutathione peroxidase activity appeared less useful than measurements on erythrocytes. Complicating factors other than Se intake which affect tissue glutathione peroxidase activity were reviewed. 21 references, 2 tables.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 6298518
• Report Number(s): CONF-750603-
• Conference Information: Journal Name: Trace Subst. Environ. Health; (United States) Journal Volume: 9
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLASMA
BODY
BODY AREAS
BODY FLUIDS
BRAIN
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
CRYSTALLINE LENS
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ERYTHROCYTES
EYES
FACE
GASTROINTESTINAL TRACT
GLANDS
GONADS
HEAD
HEART
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
KIDNEYS
LIVER
LUNGS
MALE GENITALS
MAMMALS
MATERIALS
MUSCLES
NERVOUS SYSTEM
NUTRITIONAL DEFICIENCY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEROXIDASES
PORPHYRINS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RUMINANTS
SELENIUM
SEMIMETALS
SENSE ORGANS
SHEEP
STOMACH
TESTES
VERTEBRATES