Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in tissues of Balb/C mice

Conference · Mon Mar 11 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5371063

Spallholz, J E; Roveri, A; Yan, L; Boylan, L M; Kang, C R; Ursini, F ^[1]

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1. Texas Tech Univ., Lubbock (United States) Univ. of Padua (Italy)

The two selenium (Se) enzymes glutathione peroxidase (GPx) and phospholipid hydroperoxide glutathione peroxide (PHGPx) were assayed in tissues and organ homogenates of female Balb/C mice fed torula yeast diets containing 0.008, 0.2 and 1.0 ug/g Se as selenite for nine months. GPx activity was detected in all tissues and organs whereas PHGPx activity was not detectable in lung, large intestine, eye or thymus tissue. GPx activity nearly always exceeded PHGPx activity when tissues or organs contained both enzymes irrespective of dietary Se treatment. GPx activity in tissues was generally more susceptible to the dietary Se deficiency than was PHGPx activity when expressed as a percentage of the activity found in tissues and organs of mice fed supplemented Se diets. This limited study suggests that dietary Se may be more valued in supporting PHGPx activity than GPx activity in the course of a protracted dietary Se deficiency.

• OSTI ID: 5371063
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:4
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
DIET
DRUGS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLUTATHIONE
MAMMALS
METABOLISM
MICE
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PEPTIDES
PEROXIDASES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
SELENIUM
SEMIMETALS
VERTEBRATES