The ocular inflammatory response to endotoxin is not altered when glutathione peroxidase activity is decreased

Conference · Mon Mar 11 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5372014

Grimes, A M; McGahan, M C; Smith, M G ^[1]

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1. North Carolina State Univ., Raleigh (United States)

Selenium (Se) is an essential trace element and an integral part of the enzyme glutathione peroxidase (GPx). GPx is an antioxidant which scavenges both hydroperoxide and lipid peroxides. The purpose of the current study was to determine if decreased GPx activity affects the ocular inflammatory response. New Zealand White rabbits were fed either a purified Se deficient or Se adequate diet for 9 weeks. After 9 weeks, plasma Se levels were 0.151 {plus minus} 0.0130 {mu}g/ml in the deficient diet group compared to 0.217 {plus minus} 0.015 {plus minus} 0.87 U compared with 25.43 {plus minus} 1.77 U in the basal diet group. At this point, ocular inflammation was induced by intravitreal injection of endotoxin. Twenty-four hours later, despite a 40% decrease in plasma and a 30% decrease in intraocular fluid GPx activity, there was no significant difference in inflammatory parameters between the groups. However, it is possible that a further decrease in GPx activity could have some effect on the inflammatory response.

• OSTI ID: 5372014
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:4
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
EYES
FACE
HEAD
INFLAMMATION
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PATHOLOGICAL CHANGES
PEROXIDASES
PROTEINS
RABBITS
SELENIUM
SEMIMETALS
SENSE ORGANS
SYMPTOMS
VERTEBRATES