Role of mobile passenger lymphocytes in the rejection of renal and cardiac allografts in the rat. A passenger lymphocyte-mediated graft-versus-host reaction amplifies the host response

Journal Article · Sat Mar 01 04:00:00 EST 1980 · Transplantation; (United States)

OSTI ID:6297913

van Vrieshilfgaarde, R; Hermans, P; Terpstra, J L; van Breda Viresman, P J

It is demonstrated that passenger lymphocytes migrate out of rat renal allografts into host spleens in a radioresistant fashion. These mobile passenger lymphocytes within BN kidney and heart transplants are immunocompetent, since they elicit a graft-versus-host (GVH) reaction in the spleens of (LEW x BN)F2 hybrid hosts. The greater GVH reaction in (LEW x BN)F1 recipients of BN kidneys reflects the greater number of mobile passenger lymphocytes in the kidney when compared to the heart. The mobile passenger lymphocytes within BN renal allografts also cause a proliferative response in the spleens of the LEW hosts as well as an accelerated rejection of BN renal allografts when compared to BN cardiac allografts, for the differences between BN kidney and heart, both in terms of splenomegaly elicited in LEW as well as tempo of rejection, are abolished by total body x-irradiation of the donor with 900 rad. Results indicate that a mobile passenger lymphocyte mediated GVH reaction in the central lymphoid organs of the host augments the host response to allogenic kidneys and contributes materially to first-set renal allograft rejection; this GVH reaction on the other hand is not conspicuously present in LEW recipients of BN cardiac allografts and has therefore little effect on first-set cardiac allograft rejection.

• Research Organization: Univ. Hospital, Leiden, Netherlands
• OSTI ID: 6297913
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 29:3; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GRAFT-HOST REACTION
HEART
IONIZING RADIATIONS
KIDNEYS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATIONS
RATS
RODENTS
SOMATIC CELLS
SURGERY
TRANSPLANTS
VERTEBRATES
X RADIATION