Splenic microenvironment and self recognition as factors in allograft rejection in rats. A study using indium-111-labeled cells

Journal Article · Sat Nov 01 00:00:00 EST 1986 · Transplantation; (United States)

OSTI ID:6845086

Pollak, R; Blanchard, J M; Lazda, V A

Splenectomy facilitates organ allograft survival in some rat strains, and in weak donor-recipient histoincompatible pairs. We have found using a heart spleen twin graft model, using ACI rats as recipients and Lewis rats as donors, that the transplanted heart will survive in most recipients after delayed host splenectomy. The presence of a viable mass of splenic tissue will allow rejection to proceed only when the transplanted spleen is of host origin, and not when it comes from the donor (i.e., when it is allogeneic). The use of 111In-labeled cells has allowed us to show that lymphocyte traffic and trapping is markedly altered in the transplanted allogeneic spleens, when compared with control transplanted syngeneic spleens. Thus, despite the presence of the splenic ''microenvironment,'' cardiac allograft rejection does not occur in the absence of syngeneic splenic tissue. We conclude that the role of the spleen in the immune response is to facilitate the recognition of self and the acquisition of alloreactivity in weak responder rat strains and donor-recipient pairs.

• Research Organization: Univ. of Illinois College of Medicine at Chicago
• OSTI ID: 6845086
• Journal Information: Transplantation; (United States), Vol. 5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
TRANSPLANTS
SPLEEN
BIOLOGICAL MODELS
GRAFT-HOST REACTION
INDIUM 111
RATS
SPLENECTOMY
SURVIVAL TIME
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SURGERY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics