Mechanisms of allograft rejection of corneal endothelium
Journal Article
·
· Invest. Ophthalmol. Visual Sci.; (United States)
OSTI ID:6725254
The local intraocular graft-vs.-host (GVH) reaction, involving the destruction of the corneal endothelial cells of the rabbit host by sensitized donor lymphoid cells, has been used to study the mechanism of corneal allograft rejection. Pretreatment of donor cells with a specific mouse monoclonal hybridoma anti-T cell antibody and complement suppresses the destructive reaction, suggesting that a cellular-immune mechanism is primarily involved. Pretreatment of donor cells with mitomycin-C completely abolishes the local GVH reaction, indicating that the effector lymphocytes must undergo mitosis within the eye before they can engage in target cell destruction. Finally, studies of the local GVH reaction in irradiated leukopenic recipients or in preinflamed rabbit eyes suggest that host leukocytes may contribute nonspecifically to enhance the destructive process. These studies show that the local ocular GVH reaction may provide a useful model for the study of the mechanisms involved in the rejection of corneal allografts.
- Research Organization:
- Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD
- OSTI ID:
- 6725254
- Journal Information:
- Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 23:1; ISSN IOVSD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIGEN-ANTIBODY REACTIONS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CELL DIVISION
CONNECTIVE TISSUE CELLS
CORNEA
DRUGS
ENDOTHELIUM
EYES
FACE
GRAFT-HOST REACTION
GRAFTS
HEAD
IMMUNITY
IMMUNOSUPPRESSION
IRRADIATION
LEUKOCYTES
LOCAL IRRADIATION
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MITOMYCIN
MITOSIS
ORGANS
RABBITS
SENSE ORGANS
SKIN
SOMATIC CELLS
TISSUES
TRANSPLANTS
VERTEBRATES
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIGEN-ANTIBODY REACTIONS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CELL DIVISION
CONNECTIVE TISSUE CELLS
CORNEA
DRUGS
ENDOTHELIUM
EYES
FACE
GRAFT-HOST REACTION
GRAFTS
HEAD
IMMUNITY
IMMUNOSUPPRESSION
IRRADIATION
LEUKOCYTES
LOCAL IRRADIATION
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MITOMYCIN
MITOSIS
ORGANS
RABBITS
SENSE ORGANS
SKIN
SOMATIC CELLS
TISSUES
TRANSPLANTS
VERTEBRATES