Lung allograft rejection in the rat. I. Accelerated rejection caused by graft lymphocytes
Journal Article
·
· Transplantation; (United States)
OSTI ID:5149199
To find out to what extent rejection of lungs differs from that of other organs, functional rejection of lung allografts was studied in five combinations of inbred rat strains. Rejection could be monitored accurately by perfusion scintigraphy, and equally well by chest roentgenography. The rejection of lung grafts was found to proceed remarkably fast, when compared with heart grafts, in combinations with strong RT1-incompatibilities. This accelerated rejection pattern could be converted into rejection at a normal pace by pretreatment of the donor with 10 Gy roentgen irradiation one day before transplantation. Donor pretreatment depleted the lung graft's bronchus-associated lymphoid tissue (BALT) of lymphocytes. When grafts were depleted of all other passenger cells as well--by retransplantation from a cyclosporine-treated intermediate host--they showed an even more reduced immunogenicity, probably because of the loss of donor-type dendritic cells. These results indicate that lymphocytes from the BALT of lung grafts are capable of accelerating the rejection response.
- Research Organization:
- Univ. Hospital, Groningen, Netherlands
- OSTI ID:
- 5149199
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 1; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
GRAFT-HOST REACTION
HEART
IRRADIATION
LEUKOCYTES
LUNGS
LYMPHOCYTES
MAMMALS
MATERIALS
ORGANS
PERFUSED ORGANS
RADIOISOTOPE SCANNING
RATS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
SOMATIC CELLS
TRANSPLANTS
VERTEBRATES
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
GRAFT-HOST REACTION
HEART
IRRADIATION
LEUKOCYTES
LUNGS
LYMPHOCYTES
MAMMALS
MATERIALS
ORGANS
PERFUSED ORGANS
RADIOISOTOPE SCANNING
RATS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
SOMATIC CELLS
TRANSPLANTS
VERTEBRATES