UVB pretreatment of rat bone marrow allografts. Prevention of GVHD and induction of allochimerism and donor-specific unresponsiveness
Journal Article
·
· Transplantation; (USA)
- Columbia Univ. College of Physicians and Surgeons, New York, NY (USA)
Ultraviolet B irradiation has been used to pretreat blood and islets to prevent subsequent graft rejection. In this study the optimal dose of UVB irradiation of bone marrow was determined in syngeneic recipients and was subsequently applied to in-vitro treatment of bone marrow allografts. UVB pretreatment of donor bone marrow inoculum led to complete prevention of GVHD in allogeneic rat recipients without major marrow or other toxicity. Long-standing recipients of allogeneic UVB-BM became stable adult chimeras. The recipients of allogeneic BM were populated by donor-type peripheral blood lymphocytes and did not reject host or donor-type heart grafts. The BM allograft recipients were immunocompetent as measured by their ability to normally reject third-party cardiac allografts. We suggest that the prevention of GVHD and induction of stable chimerism in adult recipients of allogeneic UVB-BM may be mediated by suppressor mechanisms.
- OSTI ID:
- 7043342
- Journal Information:
- Transplantation; (USA), Journal Name: Transplantation; (USA) Vol. 49:5; ISSN 0041-1337; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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Wed Aug 01 00:00:00 EDT 1984
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Increased incidence of murine graft-versus-host disease after allogeneic bone marrow transplantation by previous infusion of syngeneic bone marrow cells
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Mon Oct 01 00:00:00 EDT 1984
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Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD
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·
Sat Oct 01 00:00:00 EDT 1988
· J. Immunol.; (United States)
·
OSTI ID:6557328
Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
BONE MARROW CELLS
CHIMERAS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNITY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MOSAICISM
ORGANS
RADIATION CHIMERAS
RADIATION DOSES
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SOMATIC CELLS
TISSUES
TRANSPLANTS
ULTRAVIOLET RADIATION
VERTEBRATES
Cells
& Tissue Culture
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
BONE MARROW CELLS
CHIMERAS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNITY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MOSAICISM
ORGANS
RADIATION CHIMERAS
RADIATION DOSES
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SOMATIC CELLS
TISSUES
TRANSPLANTS
ULTRAVIOLET RADIATION
VERTEBRATES