Emission computed tomography: a new technique for the quantitative physiologic study of brain and heart in vivo

Technical Report · Sun Jan 01 04:00:00 EST 1978

DOI:https://doi.org/10.2172/6290057· OSTI ID:6290057

Phelps, M E; Hoffman, E J; Huang, S C; Schelbert, H R; Kuhl, D E

Emission computed tomography can provide a quantitative in vivo measurement of regional tissue radionuclide tracer concentrations. This facility when combined with physiologic models and radioactively labeled physiologic tracers that behave in a predictable manner allow measurement of a wide variety of physiologic variables. This integrated technique has been referred to as Physiologic Tomography (PT). PT requires labeled compounds which trace physiologic processes in a known and predictable manner, and physiologic models which are appropriately formulated and validated to derive physiologic variables from ECT data. In order to effectively achieve this goal, PT requires an ECT system that is capable of performing truly quantitative or analytical measurements of tissue tracer concentrations and which has been well characterized in terms of spatial resolution, sensitivity and signal to noise ratios in the tomographic image. This paper illustrates the capabilities of emission computed tomography and provides examples of physiologic tomography for the regional measurement of cerebral and myocardial metabolic rate for glucose, regional measurement of cerebral blood volume, gated cardiac blood pools and capillary perfusion in brain and heart. Studies on patients with stroke and myocardial ischemia are also presented.

• Research Organization: California Univ., Los Angeles (USA). Lab. of Nuclear Medicine and Radiation Biology
• Sponsoring Organization: US - Energy Research and Development Administration (ERDA)
• DOE Contract Number: EY-76-C-03-0012
• OSTI ID: 6290057
• Report Number(s): UCLA-12-1176
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL MODELS
BLOOD FLOW
BODY
BRAIN
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHEMICAL ANALYSIS
COMPUTERS
DESIGN
DIAGNOSTIC TECHNIQUES
DISEASES
HEART
IMAGE SCANNERS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MEASURING METHODS
METABOLISM
Medicine
NERVOUS SYSTEM
ORGANS
QUANTITATIVE CHEMICAL ANALYSIS
RADIOISOTOPE SCANNERS
RADIOISOTOPES
RESOLUTION
SENSITIVITY
SPATIAL RESOLUTION
TOMOGRAPHY
TRACER TECHNIQUES
Unsealed Radionuclides in Diagnostics