Regional myocardial blood flow, metabolism and function assessed noninvasively by positron emission tomography

Technical Report · Sun Dec 31 23:00:00 EST 1978

DOI:https://doi.org/10.2172/5612866· OSTI ID:5612866

Schelbert, H R; Phelps, M E; Hoffman, E; Huang, S; Kuhl, D E

Positron emission computed tomography is a new technique for the noninvasive measure of myocardial blood flow, mechanical function and, in particular, metabolism. The capability of this new study means is due to the technological innovations of the imaging device and the availability of radioactive tracers that are specific for blood flow and metabolism. The device permits recording of cross-sectional images of the left ventricular myocardium that reflect quantitatively regional tracer tissue concentrations. By employing tracer kinetic models this new technique permits the measurement of regional glucose and fatty acid metabolism of the heart. While already an important new tool for investigative studies into cardiac physiology and pathophysiology, the clinical utility of positron emission tomography remains to be defined.

• Research Organization: California Univ., Los Angeles (USA). Lab. of Nuclear Medicine and Radiation Biology; California Univ., Los Angeles (USA). School of Medicine
• DOE Contract Number: EY-76-C-03-0012
• OSTI ID: 5612866
• Report Number(s): UCLA-12-1230
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD FLOW
BODY
CARBOHYDRATES
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CAT SCANNING
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
ECAT SCANNING
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEART
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEASURING METHODS
METABOLISM
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
MUSCLES
MYOCARDIUM
NITROGEN 13
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN 15
OXYGEN ISOTOPES
PATIENTS
PHOTON EMISSION SCANNING
PHOTON TRANSMISSION SCANNING
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SACCHARIDES
TOMOGRAPHY