Influence of vitamin E on the lung fatty acids of rats exposed to ozone

Journal Article · Sat Jan 01 04:00:00 EST 1972 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1972.10666077· OSTI ID:6287278

Roehm, J N; Hadley, J G; Menzel, D B

Rats were fed basal diet that was either free of vitamin E or containing 100 mg/kg of the vitamin, and then exposed to 1.0 ppm O/sub 3/. Mean survival time (50%) was 8.2 days in depleted group and 18.5 days in supplemented group. Protective action was thus demonstrated. O/sub 3/ toxicity symptoms included respiratory difficulty, increased respiratory rate, massive pulmonary edema and hemorrhage, and death. Other rats were exposed to 0.5 ppm for 6 wk. O/sub 3/ caused slight increase in lung weight (% body wt.) of E-supplemented rats and pronounced increase in E-depleted rats, which also showed other signs of O/sub 3/ toxicity. Lung-tissue fatty acid changes predicting edema included increase in arachidonic acid, but other unsaturated acids remained relatively constant. While mortality protection indicates peroxidation as O/sub 3/ toxicity mechanism, fatty acid analyses show quite the opposite. (i.e., surfactant lipids stable).

• OSTI ID: 6287278
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 24; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARACHIDONIC ACID
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
OZONE
PATHOLOGY
PHYSIOLOGY
RATS
RESPIRATORY TRACT CELLS
RODENTS
VERTEBRATES
VITAMIN E
VITAMINS