Toxicity of ozone. I. Acute toxicity

Journal Article · Sun Jan 01 04:00:00 EST 1956 · Ind. Med. Surg.; (United States)

OSTI ID:6251880

Mittler, S; Hedrick, D; King, M; Gaynor, A

Mice, rats, rabbits, guinea pigs, and cats were exposed to 2 to 60 ppM O/sub 3/ (by wt) administered in exposure chamber or by funnel. Mortality was observed 1 wk after exposure. Death was usually from edema- and hemorrhage-induced asphyxiation. LD/sub 50/ for 186 2-month-old mice was 21 ppM for 3 hr; 2.18 ppM for 88 2-month-old rats; 51.7 ppM for 63 2- to 3-month-old guinea pigs; 36 ppM for 38 rabbits; and 34.5 ppM for 14 cats. Subacute toxicity was assessed by wet to dry lung wt ratio after exposure to O/sub 3/ for 18 hr. Guinea pigs had hemorrhagic lungs at 6 ppM and rats had such edema at 5 ppM. 3.3 ppM or less for 24 hr had no damaging effect on rat lungs.

• OSTI ID: 6251880
• Journal Information: Ind. Med. Surg.; (United States), Journal Name: Ind. Med. Surg.; (United States) Vol. 25; ISSN IMSUA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CATS
DISEASES
EDEMA
GUINEA PIGS
HEMORRHAGE
LUNGS
MAMMALS
MICE
MORTALITY
ORGANS
OZONE
PATHOLOGICAL CHANGES
RABBITS
RATS
RESPIRATORY SYSTEM
RODENTS
SYMPTOMS
TOXICITY
VERTEBRATES