Vitamin E: the biological and environmental antioxidant

Journal Article · Fri Dec 31 23:00:00 EST 1971 · J. Agric. Food Chem.; (United States)

DOI:https://doi.org/10.1021/jf60181a039· OSTI ID:6252079

Menzel, D B; Roehm, J N; Lee, S D

Rats fed a diet high in unsaturated fatty acids (more susceptible to oxidation) were exposed to O/sub 3/ or NO/sub 2/. Vitamin E decreased acute toxicity from O/sub 3/ or NO/sub 2/; LT/sub 50/ for tocopherol-depleted rats exposed to 1.5 ppM O/sub 3/ was 8.2 days compared with 18.5 days for those with supplementation. Those figures for rats exposed to 33 ppM NO/sub 2/ were 11.1 days vs 17 days. 0.5 ppM O/sub 3/ accelerated depletion of vitamin E from erythrocytes. Oxidant stress also evidenced by lower serum glutathione and tissue sulfhydryl content. O/sub 3/ decreased serum oleic and linoleic acid content but increased arachidonic acid content.

• OSTI ID: 6252079
• Journal Information: J. Agric. Food Chem.; (United States), Journal Name: J. Agric. Food Chem.; (United States) Vol. 20; ISSN JAFCA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD SERUM
BODY FLUIDS
CARBOXYLIC ACIDS
CHALCOGENIDES
ERYTHROCYTES
GLUTATHIONE
LINOLEIC ACID
MAMMALS
MONOCARBOXYLIC ACIDS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDES
OXIDIZERS
OXYGEN COMPOUNDS
OZONE
PEPTIDES
POLYPEPTIDES
PROTEINS
RATS
RODENTS
TOXICITY
VERTEBRATES
VITAMIN E
VITAMINS