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Influence of dietary vitamin E on the red cells of ozone-exposed rats

Journal Article · · Environ. Res.; (United States)
 [1];
  1. Univ. of Kentucky, Lexington
+ Show Author Affiliations

The effect of dietary vitamin E on the susceptibility of red blood cells to ozone exposure was studied in rats. One- and two-month-old male Sprague-Dawley rats were fed a basal vitamin E-deficient diet with or without 45 ppM vitamin E for 4 and 3 months, respectively, and were exposed to 0 or 0.8 ppM ozone continuously for 7 days. Ozone exposure resulted in a significant increase in the activities of glutathione (GSH) peroxidase, pyruvate kinase, and lactate dehydrogenase, and a decrease in GSH level in the red cells of vitamin E-deficient rats, but not in those of the supplemented group. The activities of glucose-6-phosphate dehydrogenase, catalase, and superoxide dismutase and levels of thiobarbituric acid reactants, methemoglobin, hemoglobin, and reticulocytes were not significantly altered by ozone exposure or by the nutritional status of vitamin E. The results suggest that depletion of dietary vitamin E renders animals more susceptible to ozone exposure.

OSTI ID:
5406843
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 19:1; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CATALYSIS
DATA
DATA FORMS
ENZYMES
ERYTHROCYTES
EXPERIMENTAL DATA
INFORMATION
ISOLATED VALUES
KINETICS
MAMMALS
MATERIALS
METABOLISM
NUMERICAL DATA
NUTRITIONAL DEFICIENCY
OZONE
RATS
REACTION KINETICS
RESPONSE MODIFYING FACTORS
RODENTS
TOLERANCE
TOXICITY
VERTEBRATES
VITAMIN E
VITAMINS